Transplant biopsy beyond light microscopy

Transplant biopsy beyond light microscopy

Despite its long-standing status as the diagnostic "gold standard", the renal transplant biopsy is limited by a fundamental dependence on descriptive, empirically-derived consensus classification. The recent shift towards personalized medicine has resulted in an increased demand for precise, mechanism-based diagnoses, which is not fully met by the contemporary transplantation pathology standard...

Plastic embedding of transbronchial biopsy specimens for light microscopy.

Principles of light microscopy and its use in dermatology

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Malignant mesothelioma: a comparison of biopsy and postmortem material by light microscopy and immunohistochemistry.

AIMS The diagnosis of malignant mesothelioma in pleural biopsies can be difficult. Survival is short and consequently many of these cases are submitted to necropsy to assist with medicolegal claims. This study compares the histological appearances and immunohistochemical profile of nine biopsy specimens with corresponding postmortem specimens. METHODS Archival, formalin fixed, paraffin wax em...

Beyond Range: Innovating Fluorescence Microscopy

Time-of-Flight (ToF) technologies are developed mainly for range estimations in industrial applications or consumer products. Recently, it was realized that ToF sensors could also be used for the detection of fluorescence and of the minute changes in the nanosecond-lived electronic states of fluorescent molecules. This capability can be exploited to report on the biochemical processes occurring...